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Epithelium neoplasms



1. A teenager male presents with slowly enlarging, painless nodule on his right hand’s skin. Microscopic examination of removed lesion revealed an increased number of epithelial layers, with a stroma underneath, with developed a papillomatous pattern. Identify most likely type of atypia?

A. * Tissue

B. Cellular.

C. Metabolic.

D. Functional.

E. Hystochemical

2. A 35 year-old female with a family history of colon cancer inquires about screening. Colonoscopy revealed a tumor and a tissue sample was taken for histology. Microscopic investigation has shown cells were arranged in glandular-like pattern. They exhibit cell pleomorphism, atypia, invasive growth and pathologic mitosis’s. What is the most likely diagnose?

A. *Adenocarcinoma

B. Basal-cell carcinoma

C. Solid carcinoma

D. Mucous carcinoma

E. Undifferentiated carcinoma

3. A 50-year-old female is found to have a urinary bladder neoplasm. Biopsy investigation revealed that tumor consists of thin, branching out papillae, covered with few layers of transitional cell epithelium. What is the most likely diagnose?

A. *Papilloma

B. Basal cell

C. Transitional cell carcinoma

D. Squamous cell carcinoma

E. Fibroadenoma

4. A 60-year-old postmenopausal woman has been feel unhealthy and weak for about 3 month. A gross investigation of her cervix uteri revealed a lesion and a biopsy from this area was obtained. Microscopically, a lesion composed of atypical squamous cell, many of them displayed pathological mitoses. Keratin pearl formation was also observed histologically. What is the most likely diagnose?

A. * Squamous cells carcinoma with keratinisation

B. Transitional cell carcinoma

C. Squamous cells without keratinisation

D. Adenocarcinoma

E. Anaplastic carcinoma

5. A 48-year-old woman complains to her doctor of uterine bleeding. Endometrial biopsy investigation revealed a presence of gland-forming cells with enlarged hyperchromic nuclei, cell atypia, abnormal mitoses. These cells were also determined at myometrium. What term most correctly identifies this pathological process?

A. * Adenocarcinoma of uterus.

B. Adenomatous endometrial hyperplasia.

C. Acute endometritis.

D. Placental polyp.

E. Chorionepitelioma of uterus.

6. A 39-year-old woman presented in oncology with a stomach cancer. Physical investigation revealed metastatic tumors in ovaries (Krukenberg tumors). What is most likely pattern of spread in that case?

A. *Lymphatic retrograde

B. Lymphatic orthograde

C. Gematogenous

D. Implantation

E. Along epithelium-lined surfaces

7. A 23-year-old female decided to have a surgeon’s removal of a small nodule at her leg’s skin. An operation material delivered to pathology department. A histological examination of a new growth has shown that parenchyma has been formed of integumentary epithelium with an increased amount of layers. Stroma together with epithelial proliferation forms papillae. What is the most likely form of atypism?

A. *Tissue.

B. Cellular.

C. Histochemical.

D. Functional.

E. Metabolic.

8. A 45-year old male with a family history of a gastric cancer inquires about screening. A gastroscopic examination of a patient revealed a pedunculated tumor mass 1.5 cm in diameter in the area of the lesser curvature of stomach. What kind of growth does the tumor have?

A. *Exophytic.

B. Expansive.

C. Infiltrating.

D. Appositional.

E. Endophytic.

9. A 70 year-old male is found to have a nodule at his right bronchus mucous membrane. A microscopic examination of the biopsy material from the tumor revealed the cell and tissue atypism, keratin pearls formation. What is the most likely pathologic process at biopsy material?

A. *Malignant tumor.

B. Benign tumor.

C. Hyperplasia.

D. Metaplasia.

E. Hypoplasia.

10. A 57-year-old postmenopausal woman is found to have a chronic nonhealing lesion at her portio vaginalis uteri.A biopsy was taken form this area. A histological examination of the biopsy material revealed a cellular atypism within epithelial layer, but basic membrane was unchanged. What is the most likely diagnosis?

A. *Carcinoma in situ.

B. Erosion.

C. Adenocarcinoma.

D. Papilloma.

E. Endometriosis.

11. A 15-year-old boy is found to have a small, dense, nodule at his right forearm skin. Grossly it had a papillary surface, which looked like a cauliflower. Microscopically, the tumor consists of many papillae. Parenchyma formed of integumentary epithelium with an increased amount of layers. The polarity of epithelial cells, their stratification and membrane wholeness are preserved. A connective tissue forms a stroma within a center of papillae. What is the most likely diagnosis?

A. *Papilloma.

B. Fibroma.

C. Adenoma.

D. Fibroadenoma.

E. Cystadenoma.

12. A 66-year old male lost his appetite and has been loosing his weight for about 5 months. X-ray study revealed a stomach neoplasm. Histological examination of a tumor’s biopsy showed a great amount of signet-ring cells. Name the histological variant of cancer.

A. *Adenocarcinoma.

B. Solid carcinoma.

C. Sarcoma.

D. Mucinous carcinoma.

E. Carcinoid.

13. A 45-year-old woman has a small tumor of her left breast. Histological examination of a breast biopsy revealed poorly differentiated atypical epithelial cells. They formed trabecules separated from one another by connective tissue. The cells and stroma proportion was approximately 1:1.What is the most likely histological variant of the cancer.

A. * Solid carcinoma.

B. Adenocarcinoma.

C. Epidermoid carcinoma.

D. Sccirrhous fibrocarcinoma.

E. Small cell carcinoma.

14. Histological investigation of a node in the removed mammary gland revealed complexes of atypical polymorphic epithelial cells, which had various sizes and forms. There were clear spaces at the centers of complexes. The cells had large nuclei, with presence of atypical mitoses. Diagnose the pathology.

A. *Adenocarcinoma

B. Squamous cell nonkeratinous carcinoma

C. Solid carcinoma

D. Fibroadenoma of breast

E. Nondifferentiated polymorphocellular carcinoma

15. A microscopical investigation of a tumour revealed signet-ring cells. Name a histological variant of a cancer.

A. *Mucinous carcinoma

B. Adenocarcinoma

C. Sarcoma

D. Solid carcinoma

E. Carcinoid

16. A 34-year-old woman presented with a hoarseness of a voice. A laryngoscopy revealed a tumour of a larynx. The neoplasm had a grey-white color and papillary surface. Microscopical investigation showed a new growth of a connecting tissue, covered by a stratified epithelium with the marked keratinization. Cellular atypia was absent. Most likely the tumor is:

A. *Papilloma

B. Fibroma

C. Polyp

D. Angioma

E. Angiofibroma

17. A microscopical investigation of a 50-year-old woman’s endometrial curettage material with the clinical diagnosis « ovarian – menstrual cycle’s disorder » revealed growth of glandular structures. These glands consisted of polymorphic cells with hyperchromic nuclei and mitoses figures. For what pathology the revealed histological changes are characteristic?

A. *Adenocarcinoma of uterus

B. Placental polyps

C. Acute endometritis

D. Glandular hyperplasia of endometrium

E. Chorioepithelioma of uterus

18. A 52-year-old female patient with a history of the chronic bronchitis and pneumosclerosis presented to the hospital for biopsy diagnostics. A microscopical investigation of a left bronchial’s mucous from the suspicious site revealed cellular and tissue atypia. There were also found some structures in the form of” cancer pearls”. What is the most likely pathology presented in that case?

A. * Squamous cell keratinous carcinoma of bronchus

B. Chronic polypous bronchitis

C. Bronchiectasis

D. Sharp bronchitis

E. Squamous cell metaplasia of mucous of bronchus

19. Histological investigation of a bronchial biopsy revealed a tumour which is constructed from nests of stratified epithelium’s atypical cells with some characteristic "pearls". What is the most likely diagnosis?

A. *Squamous cell keratinous carcinoma

B. Squamous cell nonkeratinous carcinoma

C. Solid carcinoma

D. Mucous carcinoma

E. Scirrhous carcinoma

20. A microscopical investigation of a breast tumour revealed that the neoplasm was constructed of undifferentiated atypical epithelial cells. These cells formed trabecules, separated by layers of a connective tissue. A parity of cells and stroma was approximately 1:1. Name a histological variant of a cancer.

A. *Solid carcinoma

B. Adenocarcinoma

C. Squamous cell carcinoma

D. Fibrocarcinoma

E. Small cell carcinoma

21. Histological investigation of the removed breast node revealed different sizes and the form complexes of atypical polymorphic epithelial cells among abundant stroma. The complexes had a clear space center. Cells were characterized by large nuclei, the increased number of nucleoli, nucleoli organizers and presence of atypical mitoses. What is the most likely diagnosis?

A. *Adenocarcinoma

B. Fibroadenoma of breast

C. Solid carcinoma

D. Squamous cell nonkeratinous carcinoma

E. Nondifferentiated polymorphic cells carcinoma

22. A post-mortem of a 59-year-old man, who died of a lung cancer, revealed plural metastases. What kind from the listed below metastases it is possible to regard as implantation (contact) one according to a mechanism of development?

A. *Multiple tumorous nodules of pleura

B. Metastasis in prebronchial, paratracheal lymphatic knots

C. Metastasis in a brain

D. Metastases in an adrenal gland

E. Invasion of tumor from bronchus in an esophagus

23. A 55-year-old man presented to a hospital with the atelectasis of a right lung’s middle lobe, resulted from the obturation of a midlobar bronchus by a node of soft tissues. A bronchoscopy revealed a new growth within an obturation zone. A microscopical investigation of a biopsy sample showed the growths of an atypical glandular epithelium with pathological mitoses, which spread in tissues underneath and a cartilage. What is the most likely disease?

A. *Bronchogenic carcinoma of lungs

B. Dysplasia of epithelium of bronchus

C. Inflammatory polyps

D. Deforming bronchitis

E. Sarcoma of bronchus

24. A 65-year-old woman presented to the hospital with the menopausal bleeding. At histological investigation revealed in the curettage material from the mucosa of her cervix uteri revealed a new growth of atypical epithelium with formation so-called " cancer pearls ". What is the most likely diagnosis?

A. *Squamous cell keratinous carcinoma

B. Adenocarcinoma

C Squamous cell nonkeratinous carcinoma

D. Mucous cancer

E. Nondifferentiated carcinoma

25. A post-mortem of a 48-year-old woman with a history of an operated stomach tumour in the past revealed markedly enlarged, dense, whitish color ovary. Histological investigation of the ovarian tissue showedutterly atypical epithelial cells, placed among layers and cords of a connective tissue. What if the most likely disease?

А. *Krukenberg's carcinoma of ovary

B. Serous cystadenocarcinoma

C. Pseudomucinous cystcarcinoma

D. Malignant thecoma

E. Malignant granular cell tumor

26. A histological investigation of a lung biopsy revealed atypical cells which form plural acinar structures and produce mucus. What histological form of a cancer of lungs takes place at the patient?

A. *High differentiated adenocarcinoma

B. Low differentiated adenocarcinoma

C. Nondifferentiated carcinoma

D. Differentiated

E. Glandular squamous cell carcinoma

27. A gastroscopy of a 37-year-old man revealed a tumorous formation 1,5 cm in diameter in a small curvature of his stomach. What character of a tumor growth?

A. *Exophytic

B. Expansive

C. Invasive

D. Infiltrating

E. Endophytic

28. Histological investigation of a biopsy from a tumor of the right bronchus’ mucous membrane revealed a cellular and tissue atypia, appearance of structures in the form of ' cancer pearls '. Define the pathological process.

A. *Malignant tumor

B. Benign tumor

C. Hyperplasia

D. Metaplasia

E. Hypoplasia

29. A histological investigation of the biopsy from cervix uteri of a 45-year-old woman revealed signs of cellular atypia with intact basal membrane. What is the most likely diagnosis?

A. *Carcinoma in situ

B. Erosion

C. Adenocarcinoma

D. Papilloma

E. Endometriosis

30. A physical examination of a 42-year-old patient revealed enlarged supraclavicular lymph nodes. A histological investigation of a lymph node biopsy showed the metastasis of a signet-ring cancer. Choose the most probable localization of a primary tumour.

A. *Carcinoma of stomach

B. Cancer of esophagus

C. Cancer of thyroid gland

D. Carcinoma of lungs

E. Carcinoma of uterine cervix

31. A female patient in a climacteric period presented with relapsing uterine bleedings. The diagnostic curettage of a uterus is executed. Microscopical investigation showed among blood glandular elements of different size and forms created by atypical cells with hyperchromatic nuclei numerous mitoses (including pathological). What is the most likely pathology?

A. *Adenocarcinoma

B. Glandular hyperplasia of endometrium

C. Choriocarcinoma

D. Adenomatous polypus

E. Signs of the interrupted pregnancy

32. A bronchoscopy of a 65-year-old patient revealed a polyp-like formation, 1,0 cm in diameter, in the proximal part of the upper lobe bronchus of his right lung. A histological research revealed the tumour which consisted from fine lymphocyte-like cells with hyperchromic nuclei. The cells grew like layers and cords. Specify, what of the listed below kinds of tumors is the most authentic?

A. *Nondifferentiated small cell carcinoma

B. Nondifferentiated large cell carcinoma

C. Squamous cell carcinoma

D. Adenocarcinoma

E. Glandular squamous cell carcinoma

33. A gastroscopic study of a 50-year-old patient revealed a crater-like lesion on small curvature in pre-pyloric zone of stomach. From a regional site of formation a biopsy is taken. биопсия. A histological investigation showed a tumor with glands-like structures of the various form and the sizes, growing into surrounding tissue. The cells had marked signs pf atypia. Name a histological variant of the presented tumor.

A. *Adenocarcinoma

B. Squamous cell carcinoma

C. Scirrhous carcinoma of stomach

D. Mucous carcinoma of stomach

E. Solid carcinoma of stomach

34. A patient presented to her physician with gradually developed plaque on a skin of a cheek. The formation had necrosis and an ulcer in the center. A histological investigation of a skin biopsy revealed a growth of atypical epithelial cells with a lot of pathological mitoses. What is the most likely diagnosis?

A. *Carcinoma of skin

B. Sarcoma

C. Papilloma

D. Trophic ulcer

E. Fibroma

35. A 48- year-old man with a history of a chronic bronchitis has died of a cachexy. A post-mortem revealed in a lumen of the right bronchus an endophytic growth of a light- grey softish tissue. Microscopic investigation showed a development of an atypical stratified epithelium with a presence of an « epithelial [epidermic] pearl, pearly body ». What is the most likely diagnose.

A. *Squamous cell keratinous carcinoma

B. Squamous cell nonkeratinous carcinoma

C. Adenocarcinoma

D. Nondifferentiated carcinoma

E. Apudoma

36. An autopsy of a 50-year-old man, who died of cancer intoxication, revealed the thickening of a stomach’s wall to 1, 2 cm. The mucosa was fixed, with ill-defined gastric folds. On a cut view a tissue was homogeneous, whitish with chondroid density. For what macroscopical form of a tumour the described changes are characteristic?

A. *Infiltrate

B. Node

C. Ulcer

D. Ulcerous-infiltration

E. Cyst

37. A histological investigation of a breast tumor’s biopsy revealed solid layers of fine epithelial cells with polymorphic nuclei and a considerable quantity of pathological mitoses. In addition, the tumor had very little stroma and a lymphocytic infiltration. Name the kind of presented tumor.

A. *Medullary carcinoma

B. Scirrhous carcinoma

C. Paget’s disease

D. Adenoma

E. Adenofibroma

38. A mucus membrane biopsy is taken from a bronchus of a 52-year-old patient. A histological investigation revealed cords of atypical epithelial cells, which grew into the tissues underneath. In the cord’s center a concentric pink color formations were determined (“cancer pearls”, “epithelial [epidermic] pearl, pearly body”). Name a kind of a tumor?

А. *Squamous cell keratinous carcinoma

В. Differentiated adenocarcinoma

C. Squamous cell nonkeratinous carcinoma

D. Melanoma

E. Transitional cell carcinoma

 







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