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DISEASE OF THE NERVOUS SYSTEM



1. An autopsy of the elderly woman revealed a massive purulent bronchopneumonia. A brain was slightly atrophic, gyri were thinned and sulci were deep. A microscopical study of a brain showed perivascular deposits of amyloid, Hirano bodies and neurofibrillary “tangles”.What is the most likely main disease?

A. *Alzheimer's disease

B. Pick's disease

C. Parkinson’s disease

D. Disseminated sclerosis

E. Lateral amyotrophic sclerosis

2. An autopsy of the 78-year-old woman revealed a massive purulent bronchopneumonia. There were numerous grey color plaques, up to 15 mm in diameter, found in the brain and spinal cord. A microscopical study of brain and spinal cord tissue showed plural perivenular sites of a demyelization with limphoplazmocytes infiltration and the plural foci of gliosis. Diagnose a basic disease.

A. * Disseminated sclerosis

B. Pick's disease

C. Parkinson’s disease

D. Alzheimer's disease

E. Lateral amyotrophic sclerosis

3. A 42- year-old forester, a week later after long stay in spring wood, presented to the hospital with a fever, a headache, consciousness disturbance and epileptoid attacks. He died in 4 days. An autopsy revealed a brain edema, plural petechial hemorrhages. A microscopical study showed perivascular and pericellular edema, plural perivascular, mainly lymphocytic, infiltrates. Diagnose the basic disease.

A. *Tick-borne encephalitis

B. Meningococcal infection

C. Poliomyelitis

D. Purulent encephalitis

E. Cerebro-vascula disease

4. An autopsy of the 68-year-old man revealed the atrophy of brain’s tissue. The cerebral atrophy mainly involved the frontal, temporal, and occipital regions. A hydrocephaly was also found. A microscopical study showed atrophic zones in the cerebral cortex, the senile (neuritic) plaques in hippocampus, neurofibrillary “tangles”, damage of neurons and Hirano bodies. What is the most likely main disease?

A. * Alzheimer's disease

B. Lateral amyotrophic sclerosis

C. Disseminated sclerosis

D. Encephalitis

E. Ganglioneuroma

5. A 75-year-old man, with a history of Alzheimer's disease, died of a bronchopneumonia. A microscopical study of the cerebral cortex revealed the senile (neuritic) plaques, neurofibrillary “tangles” and damaged neurons. What formations characterize cytoskeleton pathology of proximal dendrites at the Alzheimer's disease?

A. *Hirano bodies

B. Councilman's bodies

C. Negri bodies

D. Mallory's bodies

E. Russell bodies

6. An elderly man presented to the hospital with progressive dementia (aphrenia), with marked emotional lability; thus the focal neurologic symptoms were absent. After his death, a post-mortem revealed the cortex thinning in frontal, occipital and temporal lobes of the brain. A histological study of a brain’s tissue showed the considerable quantity of senile plaques (especially in a cortex), reduction of neurones’ sizes with cytoplasm vacuolation. In addition, the little Hirano bodies were determined in dendrites. What is the most likely pathology in the central nervous system?

A. * Alzheimer's disease

B. Lateral amyotrophic sclerosis

C. Disseminated sclerosis

D. Tick-borne encephalitis

E. Viral meningoencephalitis

 







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